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KSHV TK localizes to a reticular network in the cytoplasm that is devoid of major cytoskeletal proteins. 143B TK- cells expressing KSHV TK (panels 1, 4, 7, and 10) costained for actin (panel 2), α-tubulin (panel 5), β-tubulin (panel 8), and vimentin (panel 11). Cells counterstained with Hoechst stain are shown in panels 3, 6, 9, and 12.
