TABLE 2.
Bacteriostatic doses for linezolid against S. pneumoniae and S. aureus
| Organism and strain | MIC (mg/liter) | Mean static dose ± SE (mg/kg/24 h) | 24-h AUC (mg · h/liter) | 24-h AUC/ MICa |
|---|---|---|---|---|
| S. pneumoniae | ||||
| ATCC 10813 | 1.0 | 23.0 ± 0.02 | 22.2 | 22.2 |
| CDC141 | 1.0 | 67.2 ± 0.09 | 89.3 | 89.3 |
| CDC1325 | 0.5 | 17.8 ± 4.9 | 16.5 | 33.0 |
| CDC1396 | 1.0 | 37.6 ± 4.7 | 42.0 | 42.0 |
| CDC673 | 1.0 | 24.5 ± 0.05 | 24.1 | 24.1 |
| CDC145 | 1.0 | 33.4 ± 4.6 | 36.0 | 36.0 |
| CDC1293 | 1.0 | 38.0 ± 0.80 | 42.6 | 42.6 |
| CDC146 | 1.0 | 71.7 ± 21 | 97.1 | 97.1 |
| S. aureus | ||||
| 6538p | 2.0 | 95.2 ± 7.2 | 133.3 | 66.6 |
| 33591 | 1.0 | 119 ± 17.9 | 167.0 | 167.0 |
| MRSAb | 2.0 | 84.4 ± 15.0 | 118.0 | 59.1 |
| 25923 | 4.0 | 111 ± 14.7 | 155.0 | 38.9 |
a
For S. pneumoniae strains, the mean ± the standard deviation was 48.3 ± 28.8. For S. aureus strains, the mean ± the standard deviation was 82.9 ± 57.3.
b
Methicillin-resistant S. aureus.