FIG. 3.
Histological examination of muscles injected with Δ4SHIVKU2 DNA. The DNA elicited an intense mononuclear infiltration at the injected sites. Cellular infiltration was concentrated mostly around the fascicles along with endomysium and in severe cases along with perimysium. Panel A represents muscle sections from control saline-injected mice. Panel B shows initiation of mononuclear cell infiltration into the muscles of injected mice at day 2 postinjection. Panel C shows mild mononuclear cell infiltration around blood vessels in muscles of injected mice at day 2 postinjection. Panels D to F show intense infiltration of mononuclear cells at day 5 (D), day 7 (E), and day 10 (F) in the muscle. Panels G to I show gradual resolution of mononuclear cell infiltration at days 12, 15, and 20, respectively.