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Production of immunoregulatory cytokines in hMPV- or RSV-infected mice. BALB/c mice were infected as described in Fig. 1, and IFN-γ, IL-10, IL-17, IL-12 p70, and IL-12 p40 levels were measured in BAL fluid by using a Bio-Plex Mouse Cytokine 18-Plex panel. IFN-α and IL-18 were measured by ELISA. Graphs represent mean ± the SEM (n = four mice/group). ✽, P < 0.05; #, P < 0.01; †, P < 0.001 (when hMPV and RSV infections are compared).
