FIG. 4.

Production of binding and neutralizing antibodies in untreated monkeys inoculated with SHIV_{DH12R-Clone 8}. Virus-specific IgG (A) and IgM (B) binding antibodies were measured by ELISA using plasma samples, diluted 1:6, collected at the indicated times. OD, optical density. Neutralization of SHIV_{DH12R-Clone 8} was determined from the ³²P-reverse transcriptase activity released into the medium on day 14 from quadruplicate cultures (C). Autoradiograms of ³²P-reverse transcriptase assays, using plasma samples diluted 1:3 and collected at the indicated times, are shown.