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Administration of anti-CD20 MAb to Mamu-A*01-positive monkeys inoculated with SHIVDH12R-Clone 8 is not associated with a rapid and complete loss of CD4+ T cells. Rituxan was administered to animals H678 and CK48 4 days prior to intravenous inoculation with 5,000 TCID50 of SHIVDH12R-Clone 8. The numbers of peripheral blood CD20+ lymphocytes (A), numbers of CD4+ lymphocytes (B), and plasma viral RNA levels (C) were measured at the indicated times.
