TABLE 2.
In vivo mutations conferring rifampin resistance on S. aureus isolates of various PFGE genotypes
| Origin | PFGE genotypea | Rifampin MIC (μg/ml) | Amino acid change(s) |
|---|---|---|---|
| Germany | A | 2 | 481His→Asn |
| Germany | B | 2 | 481His→Asn |
| Germany | N | 2 | 481His→Asn |
| Germany | P | 2 | 481His→Asn |
| United States | K | 2 | 481His→Asn |
| Germany | D | 2 | 481His→Asn |
| Germany | O | 256 | 481His→Asn, 529Ser→Leu |
| France | C | 256 | 481His→Asn, 529Ser→Leu |
| France | B | 256 | 481His→Asn, 529Ser→Leu |
| Slovenia | I | 256 | 481His→Asn, 529Ser→Leu |
| Poland | J | 256 | 481His→Asn, 529Ser→Leu |
| Italy | S | 256 | 481His→Asn, 529Ser→Leu |
| Italy | Q | 256 | 481His→Asn, 529Ser→Leu |
| Germany | B | 512 | 481His→Asn, 465Gln→Arg, 529Ser→Leu |
| Germany | E | >512 | 481His→Asn, 473Ala→Thr, 477Ala→Thr |
| Germany | L | 512 | 481His→Asn, 466Leu→Ser |
| Germany | M | 512 | 481His→Asn, 466Leu→Ser |
| Germany | H | 512 | 481His→Asn, 466Leu→Ser |
| Germany | G | 512 | 481His→Asn, 466Leu→Ser |
| Italy | S | 512 | 481His→Asn, 527Ile→Met |
| Italy | R | 512 | 481His→Asn, 527Ile→Met |
| Germany | D | 512 | 468Gln→Lys |
| Germany | F | 512 | 468Gln→Lys |
a
S. aureus strains exhibiting the same macrorestriction pattern among PFGE analyses were assigned to the same PFGE genotype. The genotypes were arbitrarily denoted by capital letters.