TABLE 2.
MICs of various agents for P. gingivalis strains
| Strain | MIC (μg/ml)a
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ethidium bromide | Puro- mycin | Rifam- pin | Nor- floxacin | Oflox- acin | Cipro- floxacin | Spar- floxacin | Tetra- cycline | Mino- cycline | Ber- berine | Acri- flavine | SDS | |
| ATCC 33277 (parent)b | 5 | 12.5 | 0.012 | 4 | 0.5 | 1 | 0.4 | 0.12 | 0.05 | 32 | 2.5 | 500 |
| X-1 (xepB) | 0.6 | 3.1 | 0.003 | 2 | 0.25 | 0.5 | 0.4 | 0.06 | 0.025 | 16 | 1.25 | 125 |
| X-11 (xepA)c | 0.6 | 3.1 | 0.003 | 2 | 0.25 | 0.5 | 0.4 | 0.06 | 0.025 | 16 | 1.25 | 125 |
| T-101 (xepC) | 0.6 | 3.1 | 0.003 | 2 | 0.5 | 1 | 0.2 | 0.12 | 0.05 | 16 | 1.25 | 125 |
a
No changes seen in the MICs of the following agents for the xep mutants were seen (MICs are given in parentheses): nalidixic acid (150 μg/ml), ampicillin (0.4 μg/ml), crystal violet (5 μg/ml), chloramphenicol (10 μg/ml), cetylpyridinium chloride (10 μg/ml), kanamycin (>200 μg/ml), and streptomycin (>200 μg/ml).
b
Two other wild-type strains tested (strains W83 and 381) showed very similar susceptibility patterns.
c
The MIC pattern for mutant X-101 (xepAB::erm) was identical to those for both X-1 and X-11.