TABLE 1.
Donor | Time (h) | Amt (ng/ml) of IL-1α after treatment with the following concn (μg/ml) of telithromycin (% decreasea):
|
|||
---|---|---|---|---|---|
0 | 1 | 5 | 10 | ||
A | 3 | 0.02 ± 0.003 | 0.02 ± 0.003 | 0.02 ± 0.002 | 0.01 ± 0.001 |
6 | 0.13 ± 0.005 | 0.12 ± 0.003 (14) | 0.06 ± 0.004b (56) | 0.05 ± 0.003b (65) | |
24 | 0.10 ± 0.002 | 0.10 ± 0.005 | 0.07 ± 0.005 | 0.07 ± 0.002 | |
B | 3 | 0.04 ± 0.002 | 0.06 ± 0.002 | 0.05 ± 0.002 | 0.05 ± 0.002 |
6 | 0.20 ± 0.003 | 0.20 ± 0.007 (2) | 0.08 ± 0.003b (63) | 0.07 ± 0.003b (64) | |
24 | 0.12 ± 0.004 | 0.12 ± 0.004 | 0.12 ± 0.008 | 0.07 ± 0.006 | |
C | 3 | 0.03 ± 0.005 | 0.02 ± 0.003 | 0.02 ± 0.002 | 0.02 ± 0.001 |
6 | 0.17 ± 0.006 | 0.15 ± 0.009 | 0.10 ± 0.006 | 0.08 ± 0.002 | |
24 | 0.17 ± 0.004 | 0.18 ± 0.005 (0) | 0.15 ± 0.005b (13) | 0.14 ± 0.006b (15) | |
D | 3 | 0.02 ± 0.001 | 0.02 ± 0.002 | 0.01 ± 0.003 | 0.01 ± 0.002 |
6 | 0.05 ± 0.003 | 0.05 ± 0.002 | 0.04 ± 0.003 | 0.04 ± 0.003 | |
24 | 0.13 ± 0.005 | 0.15 ± 0.004 (0) | 0.12 ± 0.004 (6) | 0.10 ± 0.004b (20) | |
E | 3 | 0.01 ± 0.001 | 0.02 ± 0.002 | 0.01 ± 0.002 | 0.01 ± 0.001 |
6 | 0.13 ± 0.005 | 0.08 ± 0.004 | 0.07 ± 0.004 | 0.06 ± 0.004 | |
24 | 0.17 ± 0.006 | 0.17 ± 0.006 (0) | 0.13 ± 0.009b (23) | 0.10 ± 0.004b (38) | |
F | 3 | 0.16 ± 0.005 | 0.10 ± 0.007 | 0.09 ± 0.004 | 0.06 ± 0.005 |
6 | 0.13 ± 0.004 | 0.3 ± 0.005 | 0.17 ± 0.006 | 0.16 ± 0.005 | |
24 | 0.21 ± 0.006 | 0.12 ± 0.008 (7) | 0.17 ± 0.003b (20) | 0.15 ± 0.006b (28) | |
G | 3 | 0.01 ± 0.001 | 0.02 ± 0.002 | 0.01 ± 0.002 | 0.01 ± 0.002 |
6 | 0.04 ± 0.002 | 0.05 ± 0.005 | 0.04 ± 0.001 | 0.04 ± 0.002 | |
24 | 0.15 ± 0.004 | 0.14 ± 0.004 (10) | 0.10 ± 0.002b (32) | 0.09 ± 0.004b (39) | |
H | 3 | 0.03 ± 0.002 | 0.02 ± 0.002 | 0.01 ± 0.001 | 0.01 ± 0.001 |
6 | 0.05 ± 0.002 | 0.04 ± 0.005 | 0.04 ± 0.003 | 0.03 ± 0.001 | |
24 | 0.12 ± 0.002 | 0.11 ± 0.002 (11) | 0.07 ± 0.0030b (43) | 0.06 ± 0.005b (49) |
Percent decrease from the amount secreted by LPS-stimulated monocytes not treated with telithromycin.
P ≤ 0.01.