Skip to main content
. 2002 Oct;46(10):3327–3330. doi: 10.1128/AAC.46.10.3327-3330.2002

TABLE 1.

Inhibition of IL-1α secretion in LPS-stimulated human monocytes treated with different concentrations of telithromycin

Donor Time (h) Amt (ng/ml) of IL-1α after treatment with the following concn (μg/ml) of telithromycin (% decreasea):
0 1 5 10
A 3 0.02 ± 0.003 0.02 ± 0.003 0.02 ± 0.002 0.01 ± 0.001
6 0.13 ± 0.005 0.12 ± 0.003 (14) 0.06 ± 0.004b (56) 0.05 ± 0.003b (65)
24 0.10 ± 0.002 0.10 ± 0.005 0.07 ± 0.005 0.07 ± 0.002
B 3 0.04 ± 0.002 0.06 ± 0.002 0.05 ± 0.002 0.05 ± 0.002
6 0.20 ± 0.003 0.20 ± 0.007 (2) 0.08 ± 0.003b (63) 0.07 ± 0.003b (64)
24 0.12 ± 0.004 0.12 ± 0.004 0.12 ± 0.008 0.07 ± 0.006
C 3 0.03 ± 0.005 0.02 ± 0.003 0.02 ± 0.002 0.02 ± 0.001
6 0.17 ± 0.006 0.15 ± 0.009 0.10 ± 0.006 0.08 ± 0.002
24 0.17 ± 0.004 0.18 ± 0.005 (0) 0.15 ± 0.005b (13) 0.14 ± 0.006b (15)
D 3 0.02 ± 0.001 0.02 ± 0.002 0.01 ± 0.003 0.01 ± 0.002
6 0.05 ± 0.003 0.05 ± 0.002 0.04 ± 0.003 0.04 ± 0.003
24 0.13 ± 0.005 0.15 ± 0.004 (0) 0.12 ± 0.004 (6) 0.10 ± 0.004b (20)
E 3 0.01 ± 0.001 0.02 ± 0.002 0.01 ± 0.002 0.01 ± 0.001
6 0.13 ± 0.005 0.08 ± 0.004 0.07 ± 0.004 0.06 ± 0.004
24 0.17 ± 0.006 0.17 ± 0.006 (0) 0.13 ± 0.009b (23) 0.10 ± 0.004b (38)
F 3 0.16 ± 0.005 0.10 ± 0.007 0.09 ± 0.004 0.06 ± 0.005
6 0.13 ± 0.004 0.3 ± 0.005 0.17 ± 0.006 0.16 ± 0.005
24 0.21 ± 0.006 0.12 ± 0.008 (7) 0.17 ± 0.003b (20) 0.15 ± 0.006b (28)
G 3 0.01 ± 0.001 0.02 ± 0.002 0.01 ± 0.002 0.01 ± 0.002
6 0.04 ± 0.002 0.05 ± 0.005 0.04 ± 0.001 0.04 ± 0.002
24 0.15 ± 0.004 0.14 ± 0.004 (10) 0.10 ± 0.002b (32) 0.09 ± 0.004b (39)
H 3 0.03 ± 0.002 0.02 ± 0.002 0.01 ± 0.001 0.01 ± 0.001
6 0.05 ± 0.002 0.04 ± 0.005 0.04 ± 0.003 0.03 ± 0.001
24 0.12 ± 0.002 0.11 ± 0.002 (11) 0.07 ± 0.0030b (43) 0.06 ± 0.005b (49)
a

Percent decrease from the amount secreted by LPS-stimulated monocytes not treated with telithromycin.

b

P ≤ 0.01.