TABLE 5.
Demonstration of FabI mechanism of action against strains of H. influenzae and S. aureus overexpressing FabI
| Compound | MIC (μg/ml)
|
|||
|---|---|---|---|---|
| S. aureus WTa | S. aureus FabI overexpressor | H. influenzae WT | H. influenzae FabI overexpressor | |
| 2 | 8 | >32 | NTb | NT |
| 3 | 2 | >32 | NT | NT |
| 4 | <0.06 | 2 | 8 | >128 |
WT, wild type.
NT, not tested.