TABLE 2.
Intracellular accumulation of SQV, RTV, and IDV given either singly or in combination
| Drug(s) | n | Median AUC0-24 (ng · h ml−1) (range) |
Intracellular/plasma drug concn ratio |
|||
|---|---|---|---|---|---|---|
| Plasma | Intracellular | Median | 95% CIa | Range | ||
| SQV | ||||||
| All | 29 | 14,688 (147-104,034) | 36,676 (4,180-1,087,956) | 6.73 | 5.36-12.18 | 0.91-42.04 |
| Sole PI | 13 | 3,190 (147-57,876) | 31,380 (5,370-301,660) | 9.45 | 5.84-19.20 | 1.71-42.04 |
| Hard gel | 7 | 1,815 (147-16,038) | 27,480 (5,370-40,000) | 17.62 | 4.35-29.45 | 1.71-42.04 |
| Soft gel | 6 | 4,197 (3,190-57,876) | 35,408 (18,320-301,060) | 7.50 | 3.49-11.35 | 2.76-13.14 |
| SOV + RTV | 16 | 30,762 (1,972-104,034) | 126,778 (4,180-1,087,956) | 4.01 | 2.79-8.65 | 0.91-19.50 |
| RTV | ||||||
| All | 29 | 105,010 (12,480-491,680) | 94,440 (26,160-1,119,220) | 1.31 | 1.12-1.86 | 0.20-4.19 |
| Sole PI | 6 | 246,338 (79,460-491,680) | 181,601 (94,400-1,119,220) | 1.00 | 0.51-1.81 | 0.60-2.28 |
| RTV + SQV | 16 | 69,650 (12,480-234,220) | 54,646 (26,160-671,900) | 1.25 | 0.92-2.08 | 0.20-4.19 |
| RTV + IDV | 7 | 115,240 (22,116-224,680) | 151,100 (27,808-357,280) | 1.8 | 0.85-2.63 | 0.41-3.45 |
| IDV | ||||||
| All | 15 | 79,404 (17,583-190,014) | 24,834 (10,482-94,080) | 0.47 | 0.33-0.65 | 0.10-1.14 |
| Sole PI | 8 | 87,832 (17,583-190,014) | 39,561 (17,682-94,080) | 0.51 | 0.34-0.88 | 0.19-1.14 |
| IDV + RTV | 7 | 55,854 (27,880-155,944) | 14,220 (10,482-72,400) | 0.29 | 0.19-0.52 | 0.10-0.63 |
a
CI, confidence interval.