TABLE 1.

Macroscopic findings and GM, PCR-ELISA, and real-time PCR results for animals in the treated arm of the study

Day	Rat ID	Diseasea	Tissue burdenb	GM		PCR-ELISA		Real-time PCR
				Index	Resultd	Index	Result	Result
+2	1	0	0	1.250	NEG	0.207	NEG	NEG
	2	0	0	0.589	NEG	0.221	NEG	NEG
	3	0	1	1.255	NEG	0.221	NEG	NEG
+4	4	0	1.3	8.270	POS	10.329	POS	POS
	5	0	1	0.454	NEG	0.225	NEG	NEG
	6	0	0	1.648	POS	5.141	POS	NEG
+6	10	2	0	0.639	NEG	0.230	NEG	NEG
	11	1	1	7.906	POS	2.343	POS	NEG
+8	7	4	1.5	>MCc	POS	4.282	POS	NEG
	8	3	1	2.774	POS	3.906	POS	POS
	9	1	1	0.589	NEG	0.033	NEG	NEG
+10	16	4	1.9	>MC	POS	5.235	POS	NEG
	17	3	1	0.818	NEG	1.690	POS	NEG
	18	1	1	0.343	NEG	5.418	POS	NEG
+12	13	4	1.7	8.183	POS	3.455	POS	NEG
	14	3	1.45	0.220	NEG	2.235	POS	NEG
	15	2	0	>MC	POS	2.418	POS	NEG
+12	19	0	0	0.581	NEG	0.146	NEG	NEG
	20	0	0	0.427	NEG	0.244	NEG	NEG
	21	0	0	0.253	NEG	0.582	NEG	NEG
No. of infected animals with positive results/total no.					8/17		11/17	2/17

^aDisease indicates the macroscopic extent of disease in livers, graded from 0 to 4.

^bTissue burden indicates log CFU/gram of tissue cultured.

^c>MC OD was greater than the measurement capacity of the instrument. For the purposes of statistical analysis, these cases were assigned an index of 10.0. Rats 19, 20, and 21 are negative control animals in both groups.

^dNEG, negative; POS, positive.