TABLE 2.

Macroscopic findings and GM, PCR-ELISA, and real-time PCR results for animals in the untreated arm of the study

Day	Rat IDc	Diseasea	Tissue burdenb	GM		PCR-ELISA		Real-time PCR
				Index	Resultd	Index	Result	Result
+2	16	0	1.3	0.711	NEG	3.083	POS	NEG
	17	0	1.6	1.095	NEG	3.083	POS	NEG
	18	0	1.7	0.251	NEG	0.343	NEG	NEG
+4	13	2	1.3	8.751	POS	0.281	NEG	POS
	14	2	1.6	0.911	NEG	0.394	NEG	NEG
+6	10	1	1.9	0.495	NEG	0.511	NEG	NEG
	11	1	1.9	0.719	NEG	1.958	POS	NEG
	12	2	1.5	0.803	NEG	1.288	POS	NEG
+8	7	2	2	2.030	POS	1.784	POS	POS
	8	2	1.6	4.665	POS	0.946	NEG	NEG
	9	1	1	7.462	POS	1.575	POS	POS
+10	4	1	1.6	0.338	NEG	1.646	POS	NEG
	5	4	1.7	0.403	NEG	1.544	POS	NEG
	6	2	2.1	0.676	NEG	0.859	NEG	NEG
+12	1	3	2	0.503	NEG	0.762	NEG	NEG
	2	2	1.7	0.549	NEG	2.510	POS	NEG
	3	1	1.6	0.219	NEG	2.352	POS	NEG
+12	19	0	0	0.678	NEG	0.644	NEG	NEG
	20	0	0	0.200	NEG	0.752	NEG	NEG
	21	0	0	0.254	NEG	0.726	NEG	NEG
No. of infected animals with positive results/total no.					4/17		10/17	3/17

^aDisease indicates the macroscopic extent of disease in livers, graded from 0 to 4.

^bTissue burden indicates log CFU/gram of tissue cultured.

^cRats 19, 20, and 21 are negative control animals in both groups.

^dNEG, negative, POS, positive.