TABLE 3.
INH-resistant M. tuberculosis isolates with mutations in two or more genes
| No. of isolates | MIC range (μg/ml) | Mutation(s)a
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| furA | katG | inhA promoter | inhA | oxyR-ahpC | kasA | Rv0340 | iniB | iniA | iniC | efpA | ||
| 1 | 4 | 1559 C Delb,e | −15 C→T | |||||||||
| 1 | 16 | 1311 T Insc | M771 | |||||||||
| 1 | 32 | Del | −9 G→A | |||||||||
| 1 | >256 | Del | −12 C→T | |||||||||
| 5 | 0.5-32 | S315T | −15 C→T | |||||||||
| 1 | 1 | S315T | I21T | 198 T Inse | ||||||||
| 1 | 2 | S315T | −9 G→A | |||||||||
| 1 | 2 | S315T | −39 C→T | |||||||||
| 1 | 2 | S315T | 79 T Ins | |||||||||
| 1 | 16 | S315T | −17 G→T | |||||||||
| 1 | 16 | S315T | I21V | |||||||||
| 1 | 16 | S315T | G269S | 98 A Inse | ||||||||
| 1 | 0.5 | R463L | ||||||||||
| 1 | 1 | R463L | L245R | |||||||||
| 1 | 2 | R463L | I258Te | G269S | R537H | |||||||
| 1 | 4 | R463L | V1631 | |||||||||
| 1 | 16 | R463L | −15 C→T | |||||||||
| 1 | 16 | S5P | R463L | −39 C→Te | −39 C→T | |||||||
| 2 | 1-2 | S315T; R463L | −15 C→T | |||||||||
| 1 | 2 | S315T; R463L | −10 C→T | |||||||||
| 1 | 32 | S315T; R463L | −48 G→A | R537H | ||||||||
| 1 | 64 | S315T; 1329 A | −39 C→T | |||||||||
| Ins | ||||||||||||
| 1 | >256 | R463L; 1559 Ins of 64 bpd,e | −12 C→T; −39 C→T | E520Ve | ||||||||
| 1 | 4 | R463L; G491Ce | I258Te | |||||||||
| 1 | 2 | S5P | −15 C→T | |||||||||
a
Amino acid abbreviations: S, Ser; T, Thr; R, Arg; L, Leu; P, Pro; G, Gly; C, Cys; I, Ile; V, Val; M, Met; H, His; E, Glu. Nucleotide abbreviations: A, adenine; C, cytosine; G, guanine, T, thymidine.
b
Deletion (Del) of nucleotide C at position 1559.
c
Insertion (Ins) of nucleotide T at position 1311.
d
Insertion (64 bp) at position 1559.
e
Novel mutation.