TABLE 2.
Selected pharmacokinetic parameter estimates for antibiotics in lung tissues in the VISA studya
| Antibiotic | Value for parameter:
|
|||
|---|---|---|---|---|
| AUC (μg · h/ml) | AUC/MIC (h) | AUC > MIC (μg · h/ml) | T > MIC (h) | |
| Linezolid | 59.0 | 59.0 | 53.0 | 6.0 |
| Vancomycin | 48.1 | 6.0 | 11.4 | 2.0 |
| Teicoplanin | 24.9 | 3.1 | 0.0 | 0.0 |
a
MICs against VISA Mu50 were as follows: linezolid, 1; vancomycin, 8; and teicoplanin, 8 μg/ml. Pharmacokinetic parameters were calculated from arithmetic means of concentrations in lungs (mean values of four animals).