Table 3.
Associations between GDF-15 and evolution in sarcopenia determinants
| Model | Sample size | GDF-15 Coefficient | p-value | 95% CI | Time Coefficient | p-value | 95% CI | GDF-15 x Time Coefficient | p-value | 95% CI | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ALM | Model 1* | 139 | 6.61E-04 | 0.2198 | −4.0E-04, 1.72E-03 | 0.1649 | 0.3352 | −0.1715, 0.5013 | 2.2E-06 | 0.9881 | −2.8E-04, 2.85E-04 |
| Model 2¥ | 139 | 1.77E-04 | 0.7279 | −8.2E-04, 1.18E-03 | 0.1508 | 0.3762 | −0.1842, 0.4858 | 2.1E-05 | 0.8824 | −2.6E-04, 3.03E-04 | |
| Grip Strength | Model 1 | 139 | 6.0E-04 | 0.5512 | −1.39E-03, 2.61E-03 | −3.2567 | <0.0001 | −4.0778, −2.4357 | −5.8E-04 | 0.0883 | −1.25E-03, 8.8E-05 |
| Model 2 | 139 | 3.58E-04 | 0.7311 | −1.69E-03, 2.41E-03 | −3.2796 | <0.0001 | −4.0991, −2.4600 | −5.9E-04 | 0.0845 | −1.26E-03, 8.1E-05 | |
| Gait Speed | Model 1 | 139 | −4.0E-05 | 0.2922 | 1.2E-04, 3.5E-05 | −0.0033 | 0.8334 | −0.03424, 0.02765 | 1.3E-07 | 0.9921 | −3.0E-05, 2.5E-05 |
| Model 2 | 139 | −7.8E-06 | 0.8407 | −8.0E-05, 6.8E-05 | 0.001797 | 0.9101 | −0.02963, 0.03323 | −2.6E-06 | 0.8393 | −3.0E-05, 2.3E-05 | |
Abbreviations: ALM= Appendicular Lean Mass, CI= confidence interval; GDF-15= Growth Differentiating Factor-15; *Adjusted by age and sex; ¥Adjusted by age, sex, body mass index, MAPT group, vascular risk, moderate-to-vigorous physical activity levels and plasma interleukin-6 levels.