Figure 1.

Pedigree used for the whole-genome–scan linkage analysis. The pedigree consisted of four nuclear families, which included six affected patients. These four families are connected in a single subpedigree with five loops. The full pedigree was generated computationally from an Old Order Amish genealogy database and represents a portion of the simplest pedigree that connects 33 affected nuclear families to a putative founder couple who were born in the first half of the 18th century.