Table 3.
Statistical Tests of Genetic Linkage between the DRD2 Locus and Alcoholism, in 77 Combined German and Hungarian Families
|
No. of Transmissionsa |
||||||||
|
Td (P=.053) |
Tu (P=.018) |
Tc (P=.032) |
Tml (P=.025) |
|||||
| Haplotype | Transmitted | Not Transmitted | Transmitted | Not Transmitted | Transmitted | Not Transmitted | Transmitted | Not Transmitted |
| 111 | 2 | 4 | 9.3 | 6.8 | 9.5 | 7.9 | 9.0 | 7.4 |
| 112 | 8 | 17 | 11.8 | 26.6 | 13.2 | 25.8 | 13.0 | 26.0 |
| 121 | 5 | 5 | 17.7 | 11.4 | 17.4 | 10.6 | 18.0 | 11.0 |
| 122 | 3 | 6 | 8.3 | 10.3 | 9.0 | 10.8 | 9.1 | 10.6 |
| 211 | 8 | 2 | 15.1 | 8.9 | 14.8 | 9.0 | 15.0 | 9.2 |
| 212 | 54 | 39 | 68.0 | 55.8 | 70.6 | 57.3 | 71.1 | 57.3 |
| 221 | 0 | 0 | 0 | 0 | 2.5 | 3.5 | 2.0 | 3.3 |
| 222 | 10 | 17 | 18 | 28.3 | 17.2 | 29.2 | 17.0 | 29.1 |
a
Details of the four multilocus TDTs are discussed in the text and also are summarized in table 1. Data are the number of families in which the eight haplotypes are transmitted and not transmitted from the parents to the affected offspring.