TABLE 2.
PK parametersa of cethromycin in mice after oral single-dose administration
| Cethromycin dose (mg/kg) | Cmax (μg/ml) | Tmax (h)b | AUC (h · μg/ml) | Half-life (h) | Protein binding (%)c |
|---|---|---|---|---|---|
| 12.5 | 0.86 | 2.0 | 14.4 | 5.4 | 94.0 |
| 25 | 1.77 | 2.2 | 40.7 | 6.7 | 93.9 |
| 50 | 3.63 | 2.6 | 130.3 | 15.9 | 93.7 |
| 100 | 7.40 | 2.8 | 474.8 | 38.1 | 93.3 |
| 200 | 14.59 | 2.2 | 1,520.0 | 67.7 | 92.5 |
a
Data were calculated based on the population PK results obtained from NONMEM (14).
b
Tmax, time to maximum concentration of drug in serum (Cmax).
c
Data provided by Abbott Laboratories.