Figure 2.

Map of the 16q24.3 region containing the FOXC2 gene. The positions of several sequence-tagged sites and ESTs are indicated. The shaded boxes represent three forkhead genes—FOXF1, FOXC2, and FOXL1. The hatched box indicates the position of the translocation breakpoint identified in the patients with the t(Y;16) translocation and lymphedema. The translocation breakpoint is ∼120 kb distal to the FOXC2 gene. The positions of YAC 733F10, BAC 463O9, and BAC 58A18 are indicated below the map. The arrowheads indicate the positions of five PCR-based FISH probes used to fine-map the translocation breakpoint