Table 4.
Multipoint Results of the 10-cM Genome-Scan Initial Stage
| 4A. Results of MLB and MLS Multipoint Analyses for Six Diabetes-Related Phenotypes | |||||
| Intervala | Positive Markersb | Positionc(cM) | Phenotype | MLB-LOD (P) | MLS (P) |
| 1p21 | D1S206 | 141.12 | Strict-lean | 1.27 (.00777) | 1.48 (.00782) |
| 1q21-q24 | D1S484, D1S498 | 178 | Strict-lean | 2.47 (.00037) | 2.50 (.00066) |
| D1S484 | 178 | Strict | 1.23 (.00877) | 1.12 (.01911) | |
| 1q43 | D1S2785 | 276.23 | Large young-onset | 1.39 (.00575) | 1.64 (.00533) |
| 2p25 | D2S319 | 6.17 | Strict young-onset | 1.61 (.00324) | 2.02 (.00212) |
| 2p21-p16 | D2S2259, D2S391 | 75.31 | Strict | 2.28 (.0006) | 2.27 (.00116) |
| 2q24-q23 | D2S2330 | 179.22 | Large-lean | 1.25 (.00826) | 1.22 (.01507) |
| 3q27-qter | D3S1580, D3S1262, D3S1601 | 217.97 | Large young-onset | 2.97 (.00011) | 3.91 (.00002) |
| D3S1580, D3S1601 | 217.97 | Strict young-onset | 2.24 (.00067) | 2.89 (.00026) | |
| 4p16 | D4S2935, D4S412 | 12.5 | Large | 1.34 (.00643) | 1.35 (.01087) |
| 4q31 | D4S1539 | 185.99 | Large-lean | 1.87 (.00166) | 2.09 (.00175) |
| 5q31-q33 | D5S410, D5S436 | 159.43 | Large | 1.52 (.00412) | 1.67 (.00492) |
| 7q11 | D7S669 | 92.74 | Large-lean | 1.32 (.00682) | 1.68 (.00479) |
| 9q34 | D9S158 | 160.01 | Strict-lean | 1.30 (.00724) | 1.22 (.01494) |
| 10q26 | D10S1655 | 174.65 | Strict | 1.59 (.00342) | 1.24 (.01427) |
| D10S212 | 185.23 | Large | 1.22 (.00899) | 1.69 (.00472) | |
| D10S212 | 185.23 | Large-lean | 1.44 (.00504) | 1.45 (.00841) | |
| 11p15 | D11S1338 | 15.24 | Strict young-onset | 1.34 (.00648) | 1.25 (.01371) |
| 19p13 | D19S221 | 36.92 | Large young-onset | 1.20 (.00948) | 1.26 (.01358) |
| 4B. Additional Loci with MLS Score >1.17 | |||||
| Intervala | Positive Markersb | Positionc(cM) | Phenotype | MLB-LOD (P) | MLS (P) |
| 2p25 | D2S168 | 29.3 | Strict | .82 (.02621) | 1.90 (.00278) |
| 2p23 | D2S305 | 41.64 | Large | 1.16 (.0103) | 1.98 (.0023) |
| D2S305 | 41.64 | Large young-onset | .62 (.04537) | 1.60 (.00581) | |
| D2S305 | 41.64 | Strict young-onset | .80 (.02707) | 1.70 (.00459) | |
| 8q22 | D8S270 | 104.72 | Large | .97 (.01723) | 1.44 (.00865) |
| 12p11 | D12S345 | 55.56 | Large young-onset | .84 (.02447) | 1.41 (.00925) |
| 15q15 | D15S1007 | 26.78 | Strict young-onset | .74 (.03211) | 1.50 (.00753) |
| 16p11 | D16S3068 | 14.6 | Strict young-onset | 1.09 (.01253) | 1.39 (.00971) |
| 18q12 | D18S478 | 54.71 | Large young-onset | 1.09 (.0126) | 1.75 (.00401) |
| 20p13-p12 | D20S186 | 33.93 | Large young-onset | 1.14 (.01093) | 1.86 (.00312) |
| D20S186, D20S115 | 33.93 | Strict young-onset | 1.08 (.01304) | 1.68 (.00475) | |
| 20q13 | D20S178 | 66.95 | Large | .05 (.06295) | 1.72 (.00432) |
| 4C. Results of ASPEX Multipoint Analyses for Six Phenotypes | |||||
| Intervala | Positive Markersb | Positionc(cM) | Phenotype | MLB-LOD (P) | MLS (P) |
| Xp11-p21 | DXS991 | 89.34 | Large | 1.67 (.00491) | |
| DXS991 | 89.34 | Strict | 1.56 (.00643) | ||
a
Chromosomes locations were determined from the map available in the Genome Database and the CEDAR database.
b
When several markers per line are shown, the first one is the nearest to the top of the peak.
c
Map positions of the nearest marker to the top of the peak, obtained from sex-averaged maps compiled by Généthon.