Skip to main content
. 2005 Nov 25;1(5):e69. doi: 10.1371/journal.pgen.0010069

Figure 4. Effect of Nicotinamide on Life Span Extension by CR.

Figure 4

(A) Nicotinamide shortens the life span of wild-type cells. Replicative life span analysis for BY4742 wild-type and sir2Δ cells on 2% glucose containing or lacking 5 mM nicotinamide (nic). Mean life span is shown in parentheses.

(B) Nicotinamide partially prevents Sir2-independent life span extension by CR. Replicative life span analysis for BY4742 wild type on 2% glucose, along with sir2Δ fob1Δ double mutant cells on 2% glucose or 0.05% glucose (CR) containing or lacking 5 mM nicotinamide (nic). Mean life span is shown in parentheses.