Fig. 4.

Model for the generation of pyramidal neurons in the SVZ. (A) Depending on the infected cells, single pyramidal neuron or four-cell clusters are revealed by ASLV infection (green) after 3 days. Red cell nuclei indicate proliferative activity. Note that the ASLV reporter virus transduces only TVA expressing mitotic cells (NEX-Cre positive progenitors). (B) Presumed lineage relationship of VZ cells (VZC), the secondary neuronal progenitors (NPII), tertiary neuronal progenitors (NPIII), and pyramidal neuron (Py). A dotted line marks the boundary between VZ and SVZ.