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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 2005 Nov 10;102(47):17251. doi: 10.1073/pnas.0509008102
PMCID: PMC1288022

GENETICS. For the article “Promoters of the murine embryonic β-like globin genes Ey and βh1 do not compete for interaction with the β-globin locus control region,” by Xiao Hu, Michael Bulger, Julia N. Roach, Susan K. Eszterhas, Emmanuel Olivier, Eric E. Bouhassira, Mark T. Groudine, and Steven Fiering, which appeared in issue 3, February 4, 2003, of Proc. Natl. Acad. Sci. USA (100, 1111–1115; first published January 13, 2003; 10.1073/pnas.0337404100), the authors note the following. It was incorrectly reported that β-major and β-minor do not change transcription level in primitive erythroid cells when either Ey or βh1 is deleted. This error is attributable to sample misidentification. Subsequent studies have shown that deletion of either Ey or βh1 mediates a 3-fold increase of β-major and β-minor mRNA expression in primitive cells. This revised conclusion supports the hypothesis that expression of the embryonic β-like globin genes influences expression of the fetal/adult β-like globin genes in primitive erythroid cells.


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