Fig. 5. ΔPAP can predict the abundance of missense protein variants.

Correlation map ΔPAP against abundance score of single–amino acid substitution variants of (A) ASPA, (B) PRKN (Parkin), and (C) PTEN. Bars show the Pearson correlation coefficient of all the scored variants against their predicted ΔPAP for a sliding window of five residues, with the coefficient value assigned to the central residue of the five. The significance of the correlation for every five-residue window was assessed by calculating a P value. Black bars indicate statistically significant Pearson correlation coefficients with P < 0.05/m, where m is the number of tests conducted for each protein. The average rASA (green line) and pLDDT (red line) of each residue window are also shown. The x axes indicate the amino acid position in each protein. The secondary structure and domain composition of each protein are shown above and below each plot, respectively.