Table 1.

Clinical Features of Affected Males

	Individual
Feature	III-2	IV-3	IV-4	IV-5	IV-6	V-3	V-4
Age (years)	71	50	46	44	39	35	21
BMIa	42	38	40	31	40	46	34
Height (percentile)	<3d	10th–25th	3d	<3d	10th	90th	50th
OFCb (percentile)	10th	50th	25th	3d	25th	25th	3d
Coarse facies	+	+	+	+	+	+	+
Puffy eyelids	+	+	+	+	+	+	+
Narrow PFsc	+	+	+	+	+	+	+
Prominent supraorbital ridge	+	+	+	+	+	+	+
Bulbous nose	+	+	+	+	+	+	+
Prominent lower lip	+	+	+	+	+	+	+
Large ears	+	+	+	+	+	+	+
Large testes	+	+	+	+	+d	+	+

^aBMI >30 is indicative of obesity.

^bOFC = occipitofrontal circumference.

^cPFs = palpebral fissures.

^dRight testis undescended.