Table 1.

Haplotype, LD Analysis, and Corrected Estimated Age of the N370S (5841A→G) Mutation in Chromosome 1q21 of Ashkenazi Jewish Patients^[Note]

							Estimated Age
			LD Analysisb				Generationsc
Marker	Allele	Distancea(θ)	pd	pn	χ2 (P value)	δ	g	g0	gc	Yearsd
D1S305	1	.024e	.586	.400	5.2 (<.5)	NS	…	…	…	…
		.023f	.586	.400	5.2 (<.5)	NS	…	…	…	…
D1S2140	4	.022	.956	.475	49.6 (<.001)	.92	3.9	6.8	10.7	268
D1S2777	1	.011	.978	.638	33.3 (<.001)	.94	5.7	8.5	14.2	355
D1S1595	5	.024	.938	.450	43.7 (<.001)	.87	5.8	6.5	12.3	308
D1S2721	3	.030	.936	.338	69.1 (<.001)	.90	2.9	6.0	8.9	223
D1S2624	4	.037e	.578	.200	70.0 (<.001)	.47	19.9	5.5	25.4	635
		.025f	.578	.200	70.0 (<.001)	.47	29.6	6.5	36.1	903

Note.— NS = not significant.

^aData from Cormand et al. (1997) and Díaz et al. (1999).

^bData from Díaz et al. (1999).

^cEstimated by equations (1), (3), and (2), respectively (see text).

^dCalculated with the assumption of 25 years/generation.

^eObtained from the Stanford G3 RH panel (Research Genetics), with the assumptions of 1cR/50 kb (Moisio et al. 1996) and 900 kb/1 cM.

^f Obtained from meiotic mapping (Cormand et al. 1997).