Table 1.
TDT of DQA1-DQB1 Haplotypes in Probands or Healthy Siblings in 526 Norwegian Families with Type 1 Diabetes
|
Probands |
Healthy Siblings |
||||||
| Haplotype DQA1-DQB1 | No. (%) T | NT | χ2 a | No. (%) T | NT | χ2 a | Heterogeneityχ2 b |
| 0301–0302 | 342 (84) | 65 | 189 | 261 (49) | 271 | 0 | 123 |
| 0501–0201 | 247 (76) | 78 | 88 | 174 (43) | 228 | 7.3 | 78 |
| 0301–0303 | 15 (54) | 13 | .1 | 13 (36) | 23 | 2.7 | 2 |
| 0102–0502 | 3 (50) | 3 | 0 | 2 (40) | 3 | .2 | .1 |
| 0401–0402 | 33 (49) | 34 | 0 | 43 (51) | 40 | .1 | .1 |
| 0102–0604 | 32 (44) | 40 | .9 | 43 (55) | 35 | .8 | 1.8 |
| 0101–0501 | 47 (29) | 115 | 29 | 110 (52) | 101 | .4 | 20 |
| 0301–0301 | 16 (25) | 48 | 16 | 38 (49) | 39 | 0 | 8.8 |
| 0201–0201 | 15 (21) | 56 | 23 | 41 (51) | 40 | 0 | 14 |
| 0103–0603 | 12 (14) | 74 | 45 | 65 (59) | 45 | 3.6 | 41 |
| 0501–0301 | 7 (13) | 47 | 30 | 32 (53) | 28 | .3 | 21 |
| 0201–0303 | 2 (8) | 22 | 17 | 14 (47) | 16 | .1 | 9.4 |
| 0101–0503 | 0 (0) | 12 | 12 | 8 (67) | 4 | 1 | 12 |
| 0102–0602 | 0 (0) | 164 | 164 | 123 (57) | 94 | 3.9 | 137 |
a
χ2>8.5 provides a corrected P<.05.
b
Heterogeneity between affected and unaffected offsprings was tested by 2 x 2 contingency tables. χ2>8.5 provides a corrected P<.05.