Figure 2.

A, Multipoint linkage analysis of a 40-cM region encompassing the NS locus on 5q32. Markers D5S2017 and D5S413 (blackened arrowheads) delineate a 5.4-cM region of linkage in which multipoint LOD scores (LOD) are >3.0. The multipoint Z_max, 10.11, was obtained with marker D5S434 (unblackened arrowhead). B, Radiation-hybrid map of NS locus. The map is oriented centromeric (cen [top]) to telomeric (tel [bottom]). The physical distances (cR) between the NS locus and each marker are indicated on the left; we based them on either the radiation-hybrid map of chromosome 5 (Whitehead Institute for Biomedical Research/MIT Center for Genome Research) or our radiation-hybrid mapping results with the Genebridge 4 panel (asterisks). The genetic distances (cM) between the markers, according to the Généthon human linkage map, are shown on the right. Notably, the positions of markers D5S2099/D5S436 and D5S434/D5S413 are slightly discordant between the two maps. The NS critical interval is denoted by the thicker vertical line.