Table 2.

Genetic Models Used in the Parametric Linkage Analysis

	Penetrance
Modela andLiabilityClass	dd	Dd	DD	Description
A:
1	.001	1	1	All affected men
2	.5	.5	.5	Unaffected men aged <75 years and all women
3	.84	.37	.37	Unaffected men aged ⩾75 years
B:
1	.00038	.0018	.0018	Affected men aged ⩽49 years at diagnosis
2	.00061	.0084	.0084	Affected men aged 50–59 years at diagnosis
3	.0032	.03	.03	Affected men aged 60–69 years at diagnosis
4	.0082	.04	.04	Affected men aged 70–79 years at diagnosis
5	.0086	.015	.015	Affected men aged ⩾80 years at diagnosis
6	.99981	.9908	.9908	Unaffected men aged ⩽49 years
7	.9968	.94	.94	Unaffected men aged 50–59 years
8	.978	.75	.75	Unaffected men aged 60–69 years
9	.921	.39	.39	Unaffected men aged 70–74 years
10	.84	.12	.12	Unaffected men aged ⩾75 years
11	.5	.5	.5	Unknown and all women

^aFor both model A and model B, disease-gene frequency f_D = .003.