Table 3.

Characteristics of HPC Families in the ICPCG Combined Analysis

			Pedigrees with Male-to-Male Transmission		No. of Affected Family Members		Pedigrees with ⩾5 Affected Family Members		Age at Diagnosis		Pedigrees with Age at Diagnosis <65 Years		Pedigrees Meeting All Three Criteriaa
Group	Total No. of Pedigrees	Total No. of Individuals	No.	%	Range	Mean	No.	%	Range	Mean	No.	%	No.	%
ACTANE	100	948	64	64.0	3–9	3.7	18	18.0	52.7–78.7	67.1	31	31.0	2	2.0
BC/CA/HI	97	748	41	42.3	3–6	3.3	7	7.2	53.7–80.3	66.9	37	38.1	2	2.0
Fred Hutchinson	150	2,174	83	55.3	3–10	4.3	47	31.3	50.8–78.0	65.9	56	37.3	15	10.0
Johns Hopkins	22	206	15	68.2	3–17	5.5	13	59.1	52.2–75.0	65.8	8	36.4	4	18.2
Mayo	159	1,141	113	71.1	3–11	4.4	56	35.2	47.3–76.8	66.3	62	39.0	17	10.7
Michigan	56	360	28	50.0	3–9	3.4	4	7.1	51.0–77.5	64.5	29	51.8	2	3.6
Tampere	32	1,091	13	40.6	3–6	3.6	4	12.5	58.5–77.7	68.2	8	25.0	1	3.1
Umeå	28	366	23	82.1	3–10	4.1	6	21.4	57.6–74.5	67.4	9	32.1	1	3.6
Utah	128	2,173	111	86.7	3–8	3.8	19	14.8	54.0–77.3	68.8	23	18.0	4	3.1
Total	772	9,207	491	63.6	3–17	4.2	174	22.5	47.3–80.3	66.8	263	34.1	48	6.2

^aThe three criteria are male-to-male transmission, age at diagnosis of <65 years, and ⩾5 affected individuals per family.