Table 5.

Parametric Multipoint Analysis

	D1S452		D1S212		D1S466		D1S158		D1S422		D1S413
Group (No. of Families)	HLOD	α	HLOD	α	HLOD	α	HLOD	α	HLOD	α	HLOD	α
Male-to-male transmission (491)	2.24	.11	2.56	.11	2.24	.11	1.81	.09	1.4	.08	1.45	.09
Non–male-to-male transmission (281)	.00	.00	.00	.00	.00	.00	.00	.00	.00	.00	.00	.00
Age at diagnosis <65 years (263)	.72	.09	1.32	.11	.59	.07	.14	.03	.09	.03	.21	.03
Age at diagnosis ⩾65 years (509)	.39	.04	.39	.04	.25	.03	.27	.03	.15	.03	.15	.03
⩾5 affected family members per family (174)	.78	.08	1.11	.09	.87	.08	.66	.07	.48	.06	.92	.10
⩽4 affected members per family (598)	.34	.05	.42	.05	.11	.02	.02	.01	0	.00	0	.00
Male-to-male transmission:
Age at diagnosis <65 years (161)	1.27	.16	2.28	.19	1.22	.13	.45	.07	.68	.08	.5	.09
Age at diagnosis ⩾65 (330)	1.08	.09	.79	.07	1.08	.09	1.39	.10	.9	.08	.96	.09
⩾5 affected family members (141)	1.35	.13	2.01	.15	1.68	.14	1.25	.11	.9	.10	1.49	.14
⩽4 affected family members (350)	.91	.10	.71	.08	.68	.08	.61	.07	.53	.07	.24	.05