Table 7.

Parametric Multipoint Analysis (LOD Assuming Heterogeneity, Model B)

	D1S452		D1S212		D1S466		D1S158		D1S422		D1S413
Stratification (No. of Families)	HLOD	α	HLOD	α	HLOD	α	HLOD	α	HLOD	α	HLOD	α
All (772)	.31	.08	.50	.10	.39	.09	.17	.05	.17	.06	.39	.10
Male-to-male transmission (491)	.84	.17	1.50	.22	1.61	.23	1.02	.17	.54	.13	.83	.18
Non–male-to-male transmission (281)	.00	.00	.00	.00	.00	.00	.00	.00	.00	.00	.00	.00
Onset at age <65 years (263)	.31	.17	.50	.16	.39	.06	.17	.00	.17	.00	.39	.05
Onset at age ⩾65 years (509)	.00	.00	.04	.04	.33	.11	.44	.12	.06	.16	.43	.14
⩾5 affected family members (274)	.44	.16	.90	.22	1.26	.26	.93	.21	.45	.15	.54	.19
⩽4 affected family members (598)	.02	.03	.02	.02	.00	.00	.00	.00	.00	.00	.03	.04
Male-to-male transmission, age at onset <65 years (161)	.84	.23	.92	.23	.23	.12	.00	.01	.00	.00	.04	.06
Male-to-male transmission, ⩾5 affected family members (141)	.61	.20	1.33	.30	1.82	.35	1.31	.28	.70	.22	.90	.27
Male-to-male transmission, age at onset <65 years, ⩾5 affected family members (48)	.52	.25	.86	.33	.41	.22	.02	.05	.00	.01	.03	.06