Figure 1.

Analyses of exon skipping in patients OS1, MD1, and MD2. The region from exon 4 to exon 9 in the ATP7A cDNA sequence was PCR-amplified from cDNA obtained from the three patients (see Materials and Methods). cDNA from an unaffected person was used as a control (C). The PCR products were separated on a 3% Metaphor gel and visualized by ethidium bromide staining. Lane M, φX174DNA-HaeIII digest.