Figure 2.

Missense mutations and intraexonic SNPs in human PPOX. The amino acid sequence for the human enzyme (1) was compared with those of the mouse (2), Saccharomyces cerevisiae (3), Myxococcus xanthus (4), Bacillus subtilis (5) Mycobacterium tuberculosis (6), Propionibacterium freundenreichii (7), Nicotiana tabacum I (plastid) (8), Nicotiana tabacum II (mitochondria) (9), and Arabadopsis thaliana (10). Comparisons are shown only for mutated residues; numbers refer to the human sequence; letters above numbers denote mutant residues. Intraexonic polymorphisms (P256R [256] and R304H [304]) are in italics. A pair of vertically stacked asterisks (**) denotes a conserved residue, and a single asterisk (*) denotes a highly conserved residue. Sequences were aligned by Clustal W1.7 (Thompson et al. 1994).