Table 2.
SNPs in the Human PPOX Gene
| Exon/Intronand Positiona | Screening Method | Allele(Frequency) |
| Exon 1: | ||
| −253 | Direct sequencing | G (1.00) |
| C (0.0) | ||
| −247 | Direct sequencing | A (.46) |
| C (.54) | ||
| −246 | Direct sequencing | G (1.00) |
| T (.00) | ||
| −151 | Direct sequencing | G (.93) |
| T (.07) | ||
| −118 | Direct sequencing | C (.84) |
| G (.16) | ||
| Intron 2: | ||
| IVS2−47 | HDA | G (.61) |
| C (.39) | ||
| Intron 4: | ||
| IVS4−327 | HinfI digestion | G (.94) |
| A (.06) | ||
| Intron 6: | ||
| IVS6−150 | SfcI digestion | T (.96) |
| C (.04) | ||
| IVS6−237 | Direct sequencing | A (.73) |
| C (.27) | ||
| Exon 7: | ||
| 767 (P256R)b | HDA | C (.95) |
| G (.05) | ||
| Intron 8: | ||
| IVS8+57b | DGGE | A (.96) |
| C (.04) | ||
| Exon 9: | ||
| 911 (R304H) | DGGE | G (.61) |
| A (.39) | ||
| Intron 10: | ||
| IVS10−22b | DGGE | G (.97) |
| C (.03) |
a
Nucleotides are numbered according to the PPOX cDNA sequence (see “Numbering System” subsection in text).
b
Previously unrecognized SNPs.