Figure 1.

Pedigree of French GEFS+ family showing haplotype analysis for 13 markers on chromosome 2q. Markers are listed top to bottom from centromere to telomere. For each marker, the alleles are numbered on the basis of sizes reported on CEPH families (Généthon). Novel alleles were assigned numbers after the last reported in the Généthon database. Circles denote females, squares denote males, a slashed symbol denotes a deceased subject, blackened symbols denote GEFS+ patients, half-blackened symbols denote isolated FS patients, a question mark (?) denotes possible seizures reported by relatives (no medical records), a bracketed subject denotes an adopted child, and bracketed allele numbers denote deduced alleles. The boldfaced bars represent the GEFS+ haplotype. An arrow indicates the proband.