Figure 2.

Pedigrees of families with FOP with genotypes for markers from chromosome 4q27-31. Standard pedigree notation is used: circles and squares denote females and males, respectively; blackened symbols indicate affected individuals; and generations are indicated by Roman numerals to the left of the pedigrees (only individuals from whom genotyping data was obtained are numbered). Haplotypes for the markers shown on the left are listed below the symbols for the family members. The haplotype cosegregating with the disorder in each family is boxed.