Figure 4.

Localization of the FOP-linked interval on the long arm of human chromosome 4. Schematic representation of the 4q27-31 region shows some of the markers used in the genetic linkage analysis. The genetic distances between the markers are indicated and the cumulative genetic distances (in cM; pter is 0 cM) for the markers defining the proximal and distal boundaries of the linked interval are shown in parentheses, under the marker names. Blackened squares denote regions of allele sharing among affected individuals; open squares represent recombinant regions. Crossovers in individual III-4 from family 3 identified the proximal boundary, and those in individual III-2 from family 3 identified the distal boundary.