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. 1999 Dec 22;66(1):279–292. doi: 10.1086/302698

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© 2000 by The American Journal of Human Genetics. All rights reserved.

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Sensitivity of the orthogonal test to association. Sensitivity is defined as , where α is the significance level exceeded by 80% of simulated data sets. The total number of offspring varied between 240 and 1,920 (in increments of 240 children). Results were plotted for sib-pair families in which parental genotypes were available for analysis (squares) and for sib-pair (diamonds), sib-triad (triangles), and sib-quad (circles) families in which parental genotypes were not available for analysis. The proportion of phenotypic variance attributable to residual sibling resemblance (s²) was .30. The major-gene effect (h²) was .10 in panel A, .05 in panel B, and .025 in panel C, Each plotted data point corresponds to 1,000 simulated data sets. For convenience, a least-squares straight line has been plotted through each set of data points.

Inline graphic — Sensitivity of the orthogonal test to association. Sensitivity is defined as , where α is the significance level exceeded by 80% of simulated data sets. The total number of offspring varied between 240 and 1,920 (in increments of 240 children). Results were plotted for sib-pair families in which parental genotypes were available for analysis (squares) and for sib-pair (diamonds), sib-triad (triangles), and sib-quad (circles) families in which parental genotypes were not available for analysis. The proportion of phenotypic variance attributable to residual sibling resemblance (s²) was .30. The major-gene effect (h²) was .10 in panel A, .05 in panel B, and .025 in panel C, Each plotted data point corresponds to 1,000 simulated data sets. For convenience, a least-squares straight line has been plotted through each set of data points.