Figure 1.

In situ immunodetection of phosphorylated serine 780 on pRb in Tg26 kidneys. Phospho-pRb (Ser780) is not detected in the nuclei of epithelium of normal kidneys (A), but is readily detected in podocytes (short arrows) and tubular epithelial cells (long arrows) in hyperplastic nephrons of diseased transgenic kidneys at cortical (B), juxta-medullary (C), and medullary (D) depths. The prominent staining in many, but not all nuclei, is characteristic of asynchronously proliferating cells. (magnification = 40×)