Table 4.
Comparison of Autosomal Type-Specific Mutation Rates Derived from U.K. Hemophilia B Population and Interspecies Divergence of X and Y Chromosome Sequences[Note]
|
Type of Mutation |
||||||
| Transitions |
||||||
| Data | CpG | Non-CpG | Transversions | All Base Substitutions | Small Deletions/Insertions | All |
| A | 1.32 × 10−7 | 9.88 × 10−9 | 9.28 × 10−9 | 2.08 × 10−8 | 6.49 × 10−10 | 2.14 × 10−8 |
| B | 6.32 × 10−9 | 4.81 × 10−10 | 2.89 × 10−10 | 8.51 × 10−10 | 3.51 × 10−11 | 8.87 × 10−10 |
| A/B | 20.9 | 20.5 | 32.1 | 24.4 | 18.4 | 24.0 |
Note.—Row A: estimates of rates per base per generation, from hemophilia B, adjusted for autosomes, as explained in text. Row B: estimates of rates per base per year, from divergence of X-chromosome sequences, adjusted for autosomes, as explained in text. Row A/B: quotient of rates shown in rows A and B; this should reflect length of current human generation, if the estimates in rows A and B are sufficiently coherent.