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. 1999 Nov 18;65(6):1608–1616. doi: 10.1086/302689

Figure 1.

Figure 1

Haplotype analysis of t(11;22) carriers and offspring with der(22). A, Genetic markers that span the 11q23 region are ordered from the top (most centromeric) marker, D11S1992, to the bottom (most telomeric) marker, D11S1299. Two cases—BM97 and GM04370A—were informative for trisomy at the APOC3-tetra polymorphic locus. Haplotypes for carriers BM114 and GM06229B were determined from somatic-hybrid cell lines. B, PCR analysis of hamster-human somatic-hybrid cell lines generated from carriers BM114 and GM06229B. In both carriers (BM114 is shown), the breakpoint occurred between D11S1340 and APOC3-tetra, as is indicated by the arrow. Above the PCR analysis is the existing YAC contig on 11q23 (Tunnacliffe et al. 1999) and three BAC clones—b8203, b1001I5, and b986B20—that were positive with markers D11S1340 and APOC3-tetra. The BAC clone, b8203 (boxed), was used in FISH analysis.