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Pedigree of the large DRS family used for linkage analysis. All individuals, with the exception of the deceased and individuals (denoted by a minus sign [−]), were examined for DRS. DNA was prepared from subjects and was genotyped for linkage analysis. Individuals denoted with a plus sign (+) were used to confine the critical disease region (see fig. 5). Individual III-16 was phenotypically classified as “indeterminate.”
