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Pedigree and typing for eight chromosome 22 markers. Circles represent females, and squares represent males; unblackened symbols denote unaffected individuals, and blackened symbols denote affected individuals. Critical recombinations in individuals II-5, III-5, III-11, IV-3, and IV-7 define a 4-2-4-4-2-5 haplotype that is coinherited with the disease and that is not shared by the unaffected family members.
