Table 1.
Cancer Incidence in First- and Second-Degree Male and Female Relatives of Index Cases with Ovarian Cancer at Age <30 Years[Note]
|
No.
of Expected Cases/No. of Observed
Cases |
||||
| Invasive
Tumor |
Borderline Tumor |
|||
| Cancer Type in Index Case | First-DegreeRelatives | Second-DegreeRelatives | First-DegreeRelatives | Second-DegreeRelatives |
| Breast | 5/3.5 | 12/11 | 2/2.2 | 11/8.6 |
| Ovary | 3*/.6 | 3/2.3 | 1/.4 | 4***/1.7 |
| Pharynx | 0/.4 | 1/.6 | 0/.2 | 1/1 |
| Esophagus | 1/.4 | 0/1.7 | 0/.2 | 0/1 |
| Stomach | 1/.8 | 8/5 | 1/.4 | 4/3 |
| Colon | 2/1.2 | 10***/6 | 0/.6 | 4/3.7 |
| Rectum | 1/.8 | 0/4 | 1/.4 | 0/2.5 |
| Liver | 0/.1 | 2***/.4 | 0/.05 | 0/.3 |
| Pancreas | 2***/.4 | 1/2.3 | 1/.2 | 0/1.4 |
| Larynx | 0/.2 | 2/.9 | 0/.1 | 3*/.6 |
| Lung | 1/2.9 | 26*/16 | 1/1.4 | 5/8.9 |
| Bone | 0/.09 | 0/.2 | 0/.06 | 0/.1 |
| Connective tissue | 0/.15 | 0/.4 | 0/.09 | 0/.3 |
| Melanoma | 0/.5 | 1/1.1 | 0/.3 | 0/.8 |
| Cervix | 2/.8 | 3/2.1 | 1/.5 | 0/1.7 |
| Uterus | 0/.4 | 1/2 | 0/.3 | 4***/1.4 |
| Prostate | 2/.6 | 4/4 | 3**/.3 | 0/2 |
| Testis | 0/.3 | 0/.4 | 0/.2 | 1/.3 |
| Bladder | 1/.9 | 0/4 | 0/.4 | 1/2.4 |
| Kidney | 0/.4 | 1/1.5 | 0/.2 | 0/1 |
| Brain | 0/.6 | 3/1.7 | 0/.4 | 1/1.2 |
| Thyroid | 1/.1 | 0/.3 | 0/.08 | 0/.2 |
| Hodgkin | 0/.3 | 1/.6 | 2*/.2 | 0/.4 |
| Non-Hodgkin lymphoma | 4**/.6 | 0/1.9 | 1/.4 | 0/1.2 |
| Myeloma | 2*/.2 | 0/.9 | 0/.1 | 0/.5 |
| Leukemia | 0/.6 | 0/1.7 | 0/.3 | 0/1.1 |
| Other cancers | 0/.4 | 0/1.6 | 0/.2 | 0/1 |
| Unknown | 0/.8 | 1/4 | 0/.4 | 0/2.5 |
| All except nonmelanoma skin | 30*/19 | 80/82 | 14/11 | 39/51 |
| All except skin, breast, and ovary | 22***/15 | 65/68 | 11/8 | 24/41 |
Note.—Number of male and female relatives at risk is 1,968.
*
P<.05.
**
P<.01.
***
P<.1.