TABLE 2.
Presence of Drug Resistance Mutations and Intermediate-to-High Level Drug Resistance by Antiretroviral Drug Class and Regimen at Sample Collection Among Children Aged 0–15 in Uganda with Virologic Failure on First-Line ART, 2021
| Total (%) | ARV Present in Regimen at Sample Collection | ||||||
|---|---|---|---|---|---|---|---|
| DTG (%) | ABC (%) | AZT (%) | TDF (%) | LPV (%) | Any NNRTI (%) | ||
| All participants | 333 | 122 | 198 | 53 | 77 | 136 | 74 |
| Presence of mutations | |||||||
| Any drug resistance mutations | 271 (81.4) | 90 (73.8) | 161 (81.3) | 46 (86.8) | 59 (76.6) | 118 (86.8) | 62 (83.8) |
| NRTI mutations | 217 (65.2) | 68 (55.7) | 132 (66.7) | 40 (75.5) | 42 (54.6) | 100 (73.5) | 48 (64.9) |
| NNRTI mutations | 225 (67.6) | 74 (60.7) | 133 (67.2) | 41 (77.4) | 46 (59.7) | 97 (71.3) | 53 (71.6) |
| PI mutations | 39 (11.7) | 8 (6.6) | 23 (11.6) | 7 (13.2) | 7 (9.1) | 20 (14.7) | 10 (13.5) |
| INSTI mutations | 10 (3.0) | 8 (6.6) | 5 (2.5) | 0 (0.0) | 5 (6.5) | 1 (0.7) | 1 (1.4) |
| Mutations against 2 classes | 184 (55.3) | 58 (47.5) | 111 (56.1) | 36 (67.9) | 34 (44.2) | 83 (61.0) | 42 (56.8) |
| Mutations against 2 non-NNRTI classes | 39 (11.7) | 10 (8.2) | 24 (12.1) | 6 (11.3) | 7 (9.1) | 20 (14.7) | 8 (10.8) |
| Mutations against 3 classes | 36 (10.8) | 10 (8.2) | 21 (10.6) | 6 (11.3) | 7 (9.1) | 17 (12.5) | 8 (10.8) |
| Intermediate-high ARV resistance | |||||||
| Any intermediate-high ARV resistance | 262 (78.7) | 85 (69.7) | 156 (78.8) | 45 (84.9) | 56 (72.7) | 115 (84.6) | 61 (82.4) |
| Any non-NNRTI resistance | 217 (65.2) | 70 (57.4) | 134 (67.7) | 39 (73.6) | 41 (53.3) | 97 (71.3) | 49 (66.2) |
| Resistance to DTG | 6 (1.8) | 5 (4.1) | 3 (1.5) | 0 (0.0) | 3 (3.9) | 1 (0.7) | 0 (0.0) |
| Resistance to ABC | 85 (25.5) | 26 (21.3) | 49 (24.8) | 18 (34.0) | 16 (20.8) | 37 (27.2) | 21 (28.4) |
| Resistance to AZT | 64 (19.2) | 22 (18.0) | 29 (14.7) | 17 (32.1) | 15 (19.5) | 19 (14.0) | 22 (29.7) |
| Resistance to TDF | 29 (8.7) | 8 (6.6) | 17 (8.6) | 7 (13.2) | 5 (6.5) | 12 (8.8) | 8 (10.8) |
| Resistance to 3TC | 203 (61.0) | 62 (50.8) | 128 (64.7) | 36 (67.9) | 37 (48.1) | 96 (70.6) | 44 (59.5) |
| Resistance to LPV | 32 (9.6) | 5 (4.1) | 22 (11.1) | 5 (9.4) | 3 (3.9) | 19 (14.0) | 7 (9.5) |
| Resistance to DRV | 6 (1.8) | 1 (0.8) | 2 (1.0) | 2 (3.8) | 2 (2.6) | 2 (1.5) | 3 (4.1) |
| Resistance to EFV | 220 (66.1) | 71 (58.2) | 129 (65.2) | 40 (75.5) | 46 (59.7) | 96 (70.6) | 52 (70.3) |
| Resistance to NVP | 223 (67.0) | 73 (59.8) | 129 (65.2) | 40 (75.5) | 49 (63.6) | 96 (70.6) | 53 (71.6) |
| Resistance against 2 classes | 180 (54.1) | 58 (47.5) | 109 (55.1) | 34 (64.2) | 34 (44.2) | 80 (58.8) | 41 (55.4) |
| Resistance against 2 non-NNRTI classes | 35 (10.5) | 8 (6.6) | 23 (11.6) | 5 (9.4) | 5 (6.5) | 19 (14.0) | 7 (9.5) |
| Resistance against 3 classes | 33 (9.9) | 8 (6.6) | 21 (10.6) | 5 (9.4) | 5 (6.5) | 17 (12.5) | 7 (9.5) |