Table 1. The in vitro cytotoxic activity of trans-ferulic acid derivatives on cancerous (HepG2, Hep3B, Huh7, MCF7 and A549) cell lines and in vitro safety assay towards human normal (WI-38) cell lines using MTT assay.
| Compound | Cytotoxicity (IC50 μg mL−1) | |||||
|---|---|---|---|---|---|---|
| HepG2 | HuH7 | Hep3B | MCF7 | A549 | WI38 | |
| 4a | 19.8 ± 1.1 | 29.8 ± 1.6 | 36.1 ± 1.4 | 44.2 ± 1.8 | 26.3 ± 1.0 | 73.0 ± 1.8 |
| 4b | 53.3 ± 0.8 | 68.8 ± 0.8 | 70.6 ± 1.0 | 32.7 ± 1.5 | 40.0 ± 1.2 | 11.9 ± 0.7 |
| 4c | 72.0 ± 0.4 | 81.9 ± 1.2 | 76.3 ± 1.2 | 55.9 ± 1.6 | 49.3 ± 1.7 | 8.4 ± 0.6 |
| 4d | 7.6 ± 0.3 | 27.6 ± 1.4 | 16.9 ± 0.3 | 13.3 ± 0.6 | 16.9 ± 0.2 | 32.9 ± 0.8 |
| 4e | 1.8 ± 0.1 | 6.7 ± 0.3 | 7.1 ± 0.4 | 9.7 ± 0.1 | 7.3 ± 0.2 | 31.8 ± 0.8 |
| 6 | 45.2 ± 0.8 | 59.8 ± 0.8 | 52.0 ± 0.7 | 67.3 ± 1.7 | 83.4 ± 0.6 | 17.6 ± 0.6 |
| 12 | 4.3 ± 0.2 | 7.2 ± 0.4 | 5.7 ± 0.3 | 11.6 ± 0.5 | 8.4 ± 0.3 | 77.1 ± 1.3 |
| TFA | 40.7 ± 1.7 | 56.6 ± 2.9 | 23.6 ± 1.2 | 75.4 ± 1.9 | >100 | 77.2 ± 2.8 |
| DOX | 3.4 ± 0.1 | 9.0 ± 0.5 | 1.00 ± 0.02 | 3.1 ± 0.2 | 4.2 ± 0.1 | 23.7 ± 0.9 |