Table 3.
Results of the TDT for Polymorphisms in Candidate Genes[Note]
| Genea | Region | Polymorphism(s) | Associated Phenotype | P b | Associated Allele or Haplotype | TR:NT |
| CTLA4 | 2q31-32 | AT repeat in 3′UTR | None | NS | … | … |
| IL4 | 5q31 | nt −590(C/T) | None | NS | … | … |
| nt 8374(A/G) | None | NS | … | … | ||
| Haplotype | None | NS | … | … | ||
| IL13 | 5q31 | Arg110Glu | None | NS | … | … |
| IL9 | 5q32 | GT repeat in intron 4 | None | NS | … | … |
| CD14 | 5q32 | nt −159 (C/T) | ⩾1 +SPT | .00091 | −159T | 110:66 |
| ADRB2Rc | 5q33 | Arg16Gly | None | NS | … | … |
| Gln27Glu | None | NS | … | … | ||
| Haplotype | None | NS | … | … | ||
| TNFa | 6p21 | GT repeat 250 kb upstream of LTA | None | NS | … | … |
| HLA-DRB1 d | 6p21 | DRB1 | +SPT cockroach | .00059 | *0101 | 66:32 |
| HLA-DQA1 d | 6p21 | DQA1 | +SPT cockroach | .00017 | *0101 | 70:32 |
| HLA-DQB1 d | 6p21 | DQB1 | +SPT cockroach | .00012 | *0501 | 71:32 |
| IFNA | 9p22 | GT repeat in proximal half of IFN cluster | Symptoms | .0019 | 104 bp | 48:22 |
| FCER1B | 11q13 | CA repeat in intron 5 | None | NS | … | … |
| IFNG | 12q24 | CA repeat in intron 1 | ⩾1 +SPT | .013 | 185 bp | 39:20 |
| IGF1 | 12q24 | GT repeat in promoter region | BHR | .033 | 196 bp | 16:6 |
| NOS1 | 12q24 | AAT repeat in intron | None | NS | … | … |
| IL4RA e | 16p12 | Cys406Arg | ⩾1 +SPT | .0051 | Cys406 | 60:33 |
| Haplotype | Strict asthma | .00061 | Glu375-Ser478 | 27:7 | ||
| IFNAR | 21q22 | GT repeat in 5′UTR | None | NS | … | … |
Note.— Only the most significant result at each locus is shown; regions demonstrating strong evidence for linkage are shown in boldface.
CTLA4 = cytotoxic T lymphocyte antigen-4 (MIM 123890); IL4 = interleukin-4 (MIM 147780); IL13 = interleukin-13 (MIM 147683); IL9 = interleukin-9 (MIM 146931); CD14 = monocyte differentiation antigen CD14 (MIM 158120); ADRB2R = β2-adrenergic receptor (MIM 109690); TNFa = tumor necrosis factor–a; IFNA = interferon-α (MIM 147660); LTA = microsatellite marker upstream to lymphotoxin A gene (MIM 153440); FCER1B = Fcε receptor–β1 (MIM 147148); IFNG = interferon-γ (MIM 147570); IGF1 = insulin-like growth factor–1 (MIM 147440); NOS1 = nitrous oxide synthase–1 (MIM 163731); IL4RA = IL-4 receptor α-chain (MIM 147781); IFNAR = interferon-α receptor (MIM 107451).
NS = Not significant (P>.05).
For additional details, see Summerhill et al. (2000).
For additional details, see Donfack et al. (2000).
For additional details, see Ober et al. (2000).