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. 2005 Nov 23;115(12):3602–3612. doi: 10.1172/JCI25078

Figure 5.

Figure 5

IM patients have an augmented number of M1-specific cells in their bloodstream. PBMCs were isolated from 8 healthy donors or from 8 patients experiencing IM. Blood from IM patients was collected at various points after presentation with symptoms of IM. Please note that the number of data points for each patient is variable. (A–C) CD8+ cells were first isolated from PBMCs and then immediately stained with tetramer. The percentages of tetramer-positive cells were used to calculate the total number of either M1- or BMLF1-specific cells per ml of blood. (A) The difference between the means of the 2 subject groups was determined to be statistically significant using an unpaired, 2-tailed Student’s t test. #P = 0.02. Patient E1197 had an M1-specific memory population that grew out in culture but was undetectable ex vivo; therefore, this patient was excluded from calculation of the mean. (D) PBMCs were used to costain with CD3 and CD8+ antibodies and calculate the total number of CD8+ T cells per ml of blood.